Sesquiterpene compound α-cyperone relieves the injury in neurons undergoing oxygen-glucose deprivation/reoxygenation

The present study aimed to explore the effects of α-cyperone, an extract Cyperus rotundus, on PC12 cells, as well underlying mechanism. Following cells were induced by oxygen-glucose deprivation/reoxygena-tion (OGD/R), viability, morphology, inflammation, oxidative stress and apoptotic levels in evaluated. To mechanism treated with 3-TYP, a sirtuin-3 (SIRT3) inhibitor, then 3-TYP function α-cyperone assessed. α-Cyperone was found reduce OGD/R-induced damage neuronal viability alleviate stress, apoptosis. In addition, could elevate SIRT3 decline acetyl-forkhead box O1 (FOXO1) levels, broke aforementioned aspects cells. conclusion, activated FOXO1 deacetylation, alleviated cell